CONDITIONS WE SUPPORT
Persistent Lyme disease and tick-borne co-infections represent a complex biological challenge — Borrelia burgdorferi's ability to evade immune detection, persist in protected tissue compartments, and drive chronic inflammation requires a multi-system approach. SynergyO3 targets the biological mechanisms sustaining symptoms after initial treatment. Chronic Lyme disease support in Encinitas and San Diego, with physician-supervised EBOO ozone therapy alongside your existing care.
Quick Answer
Persistent Lyme disease is a complex, multi-system illness in which Borrelia burgdorferi evades the immune system and drives chronic inflammation even after initial antibiotic treatment. SynergyO3 targets these biological drivers with a physician-designed protocol built around EBOO ozone therapy and HOCATT™ sauna support, coordinated alongside your LLMD. Each protocol is individualized and is designed and supervised throughout by Dr. Heather Volpp, MD. Your personalized plan is discussed at your appointment and may differ from one patient to the next. If you have relevant tick-borne lab work from your own healthcare team, you can bring it in for Dr. Volpp to review.
CLINICAL PRESENTATION
Lyme disease and co-infections (Bartonella, Babesia, Ehrlichia, Anaplasma) produce symptom patterns that overlap with many other chronic conditions. Persistent or late-stage Lyme requires comprehensive biological evaluation beyond standard antibody testing. Individual results vary.
SynergyO3 works with patients managing persistent Lyme disease (Post-Treatment Lyme Disease Syndrome), Bartonella, Babesia, Ehrlichia, and patients with complex multi-system illness following tick exposure — including those with negative conventional serology who carry strong clinical presentations.
Testing may include Igenex or Galaxy Diagnostics tick-borne panels, CD57 NK cell counts (marker of chronic Lyme immune suppression), C4a and TGF-β1 (biotoxin inflammation markers), comprehensive coinfection serology, and cytokine panels showing persistent immune activation patterns.
COMMONLY OVERLAPPING CONDITIONS
CLINICAL EDUCATION
Borrelia burgdorferi is a highly evolved pathogen capable of immune evasion through multiple mechanisms: forming protective biofilms, adopting intracellular locations, persisting in collagen-rich tissues, and suppressing NK cell activity. Chronic Lyme involves a combination of persistent infection burden, immune dysregulation, and secondary neuroinflammation.
Borrelia forms protective biofilm communities that physically shield bacteria from antibiotics and immune cells. Persister cells within biofilms are metabolically dormant and highly resistant to conventional antibiotic treatment, enabling Borrelia to survive standard courses of therapy.
Borrelia actively suppresses natural killer (NK) cell activity, particularly CD57+ NK cells that serve as markers of chronic immune suppression. Low CD57 counts (<60) correlate with persistent disease burden and are used clinically to track response to treatment.
Borrelia and its co-infections cross the blood-brain barrier and activate microglial cells, generating pro-inflammatory cytokines that drive neurological symptoms. Persistent neuroinflammation may continue even when active infection burden is reduced, requiring targeted anti-inflammatory support.
KEY STATISTICS
Comprehensive intake and clinical assessment to map biological drivers.
Physician-designed sequenced protocol combining EBOO and HOCATT™ therapy.
Functional benchmarks and protocol refinement based on your response.
ROOT CAUSE INVESTIGATION
Dr. Heather Volpp evaluates each patient's complete picture — identifying which biological mechanisms are most active — before any protocol is designed. Individual results vary.
Even when Borrelia burden is reduced, dysregulated immune activation and cytokine storms continue driving symptoms. TNF-α, IL-6, and IL-8 remain elevated in many persistent Lyme patients, suggesting immune dysregulation independent of active infection burden.
Borrelia and its toxins impair mitochondrial function, reducing cellular ATP production and driving the profound fatigue characteristic of persistent Lyme. Oxidative damage to mitochondria compounds the energy deficit, creating a recovery barrier that antimicrobials alone cannot address.
Chronic Lyme generates significant oxidative stress that damages neurological tissues, depletes antioxidant reserves, and creates ongoing cellular injury. Reducing this oxidative burden is a critical component of neurological symptom recovery in persistent Lyme patients.
SUPPORT APPROACH
All protocols are physician-designed and supervised by Dr. Heather Volpp, MD. Therapies are selected based on each patient's evaluation. Results may vary.
EBOO ozone therapy is being studied for antimicrobial and immune-modulating properties, and may help support the oxidative and immune components of persistent Lyme — including biofilm-disruption support, immune modulation, and mitochondrial and antioxidant support related to the neuroinflammatory burden associated with ongoing symptoms.
The HOCATT™'s ozone steam, far-infrared, and carbonic acid combination may support lymphatic clearance of Borrelia toxins, reduce joint and tissue inflammation, and support autonomic nervous system rebalancing in Lyme patients.
YOUR PATH FORWARD
Booking is direct. Before any EBOO session, Dr. Heather Volpp reviews your complete clinical picture, and no protocol begins until that review is complete. An optional consultation is also available if you would like to discuss your case first.
A comprehensive intake with Dr. Heather Volpp reviewing your symptom timeline, prior lab work, medications, and functional status. SynergyO3 doesn't order labs — if your own healthcare team has ordered relevant labs, you're welcome to bring them in for Dr. Volpp to review as part of the bigger clinical picture.
Based on your evaluation findings, Dr. Heather Volpp designs a sequenced treatment protocol — typically combining EBOO sessions and HOCATT™ therapy at clinically appropriate intervals.
Functional benchmarks and symptom tracking guide protocol adjustments. Follow-up labs assess inflammatory markers and key biomarkers. Treatment frequency is adjusted as you progress toward your goals.
COMMON QUESTIONS
TAKE THE NEXT STEP
You can book directly. No consultation is required. Before any EBOO session, Dr. Heather Volpp, MD, Board-Certified Internal Medicine, reviews your health history and symptoms. If you would like to talk things through first, an optional consultation is available for $150, credited toward your first EBOO session once you book. Consultations typically last 15 to 30 minutes, in person or by phone.
Request Appointment →Physician-Supervised · SynergyO3 Medical · Encinitas, CA · (760) 450-4602
Individual results vary. Consult with Dr. Heather Volpp during your evaluation.
